Publication Name	World Journal of Hepatology
Manuscript ID	113475
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Blood markers vs transient elastography for liver stiffness and steatosis in metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Amal Joseph, Sunil Mathew and Harikumar R Nair
Funding Agency and Grant Number
Corresponding Author	Harikumar R Nair, Consultant, FRCP, MRCP, Department of Gastroenterology and Hepatology, Ernakulam Medical Centre, National Highway Bypass, NH 66, Palarivattom, Kochi 682028, Kerala, India. harikumnair@yahoo.co.in
Key Words	Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease; Transient elastography; Fibrosis-4 index; Aspartate transaminase to platelet ratio index; Neutrophil percentage to albumin ratio; Liver stiffness; Steatosis; Fibrosis
Core Tip	This study demonstrates that blood-based markers are cost-effective adjuvants to FibroScan for metabolic dysfunction-associated steatotic liver disease (MASLD) assessment. Fibrosis 4 and aspartate transaminase to platelet ratio index demonstrated strong correlations with liver stiffness measurement (LSM), confirming their reliability for fibrosis evaluation. Notably, neutrophil percentage-to-albumin ratio emerged as a novel marker with a specificity (97.67%) for steatosis assessment, while platelet-to-lymphocyte ratio showed an inverse correlation with LSM. These findings support integrating simple blood markers with imaging techniques for enhanced diagnostic precision, particularly valuable in primary care settings where repeated FibroScan measurements are financially or logistically challenging, addressing critical gaps in MASLD management.
Citation	Joseph A, Mathew S, Nair HR. Blood markers versus transient elastography for liver stiffness and steatosis in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; In press

Received	2025-08-27 23:19
Peer-Review Started	2025-08-27 23:20
First Decision by Editorial Office Director	2025-09-03 06:46
Return for Revision	2025-09-03 06:46
Revised	2025-09-16 16:25
Publication Fee Transferred
Second Decision by Editor	2025-12-04 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-04 06:30
Articles in Press	2025-12-04 06:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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