Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	113530
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Spatial immune cell architecture after gastric cancer surgery predicts prognosis
Manuscript Source	Unsolicited Manuscript
All Author List	Heng-Jin Yang and Ben Liu
Funding Agency and Grant Number
Corresponding Author	Ben Liu, Department of Oncology, Shuyang County Hospital of Traditional Chinese Medicine, No. 28 Middle Shanghai Road, Shucheng Street, Suqian 223600, Jiangsu Province, China. liuben5723@163.com
Key Words	Correlation analysis; Immune cell infiltration; Tumor microenvironment; Gastric cancer; Over survival
Core Tip	This retrospective cohort study evaluated spatial distribution patterns of immune cells in the tumor microenvironment after radical gastrectomy for gastric cancer using multiplex immunohistochemistry. High CD8+ T-cell density at the invasive margin, a CD8+/forkhead box protein 3+ ratio > 2.5, and low programmed death ligand 1+ tumor cell proportion were independent predictors of favorable survival. An immune prognostic score integrating these features achieved high accuracy in predicting 5-year overall survival. These findings highlight the prognostic value of immune cell spatial profiling and may guide individualized postoperative immunotherapy strategies.
Citation	Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2025; In press

Received	2025-09-23 09:02
Peer-Review Started	2025-09-23 09:02
First Decision by Editorial Office Director	2025-10-17 03:48
Return for Revision	2025-10-17 03:48
Revised	2025-11-04 14:04
Publication Fee Transferred	2025-11-12 07:33
Second Decision by Editor	2025-12-11 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 06:26
Articles in Press	2025-12-11 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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