| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Pleiotropic regulation of mitochondrial translational factors in governing proliferation, apoptosis and metastasis during cancer progression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nikita Agarwal, Uttam Sharma, Akshi Shree, Rajiv Ranjan Kumar, Jaya Kanta Gorain, Vaishnavi Vishwas, Farhana Jahan, Archna Singh, Jayanth Kumar Palanichamy, Deepam Pushpam, Radhika Bakhshi, Anita Chopra, Ranjit Kumar Sahoo, Atul Batra, Surender K Sharawat and Sameer Bakhshi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Biotechnology-Junior Research Fellowship |
DBTHRDPMU/JRF/BRT-41/I/2024-25/144 |
| Department of Biotechnology |
DBT-RA/2024-25/Call-I/RA/41 |
| University Grants Commission-Junior Research Fellowship |
211610188930 |
| Indian Council of Medical Research |
ICMR-2023-7664 |
| Indian Council of Medical Research |
ICMR-2021-9712-F1 |
| Anusandhan National Research Foundation-Science & Engineering Research Board |
CRG/2021/001887 |
|
| Corresponding Author |
Sameer Bakhshi, MD, Professor, Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, Delhi, India. sambakh@hotmail.com |
| Key Words |
Mitochondrial translation; Hallmark; Cancer; Mitochondrial translation factors; Mitochondrial ribosomal proteins |
| Core Tip |
Mitochondrial translation machinery synthesizes 13 essential oxidative phosphorylation proteins through specialized ribosomes, translation factors and mitochondrial ribosomal proteins. This review demonstrates how the dysregulation of these components drives key cancer hallmarks, including sustained proliferation through enhanced adenosine triphosphate production, resistance to cell death via disrupted reactive oxygen species/AMP-activated protein kinase signaling, and invasion and metastasis through epithelial-mesenchymal transition and cytoskeletal remodeling. Preclinical evidence supports therapeutic targeting using agents like tigecycline and nanobodies, showing significant anti-tumor effects across multiple cancer types. Translation factors emerge as both prognostic biomarkers and actionable therapeutic targets, positioning mitochondrial translation as a promising vulnerability for metabolism-based cancer treatments with clinical translation potential. |
| Citation |
Agarwal N, Sharma U, Shree A, Kumar RR, Gorain JK, Vishwas V, Jahan F, Singh A, Palanichamy JK, Pushpam D, Bakhshi R, Chopra A, Sahoo RK, Batra A, Sharawat SK, Bakhshi S. Pleiotropic regulation of mitochondrial translational factors in governing proliferation, apoptosis and metastasis during cancer progression. World J Clin Oncol 2025; In press |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
