Publication Name	World Journal of Clinical Oncology
Manuscript ID	113612
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study
Manuscript Source	Invited Manuscript
All Author List	Nobue Futawatari, Takashi Fukuyama, Yusuke Akimoto, Junji Maehara, Daisuke Hihara, Yosuke Okamoto, Yuki Yokouchi, Kei Takahashi, Manabu Watanabe and Yoshihisa Saida
Funding Agency and Grant Number
Corresponding Author	Takashi Fukuyama, PhD, Division of Biomedical Research, Kitasato University Medical Center, Arai 6-100, Kitamoto 364-8501, Saitama, Japan. fukuyam@insti.kitasato-u.ac.jp
Key Words	Gastric cancer; Kita-Kyushu lung cancer antigen-1; Multiple cancers; Prognostic marker; Tumor differentiation
Core Tip	We have previously reported that the cancer/testis antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is frequently expressed in gastric cancer (GC), with high expression observed in multiple GCs. Therefore, as a preliminary study, we investigated the relationship between KK-LC-1 expression and multiple GCs, focusing on its potential clinical utility. In the middle and lower stomach regions, KK-LC-1 expression was significantly associated with older age, differentiated histological type, and the presence of multiple cancers, with all cases in the multiple cancer group exhibiting KK-LC-1 positivity (100%). KK-LC-1 expression in primary gastric tumors suggests a higher risk of subsequent development of multiple GCs.
Citation	Futawatari N, Fukuyama T, Akimoto Y, Maehara J, Hihara D, Okamoto Y, Yokouchi Y, Takahashi K, Watanabe M, Saida Y. Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study. World J Clin Oncol 2025; In press

Received	2025-08-31 08:02
Peer-Review Started	2025-08-31 08:02
First Decision by Editorial Office Director	2025-09-29 07:36
Return for Revision	2025-09-29 07:36
Revised	2025-10-16 01:06
Publication Fee Transferred
Second Decision by Editor	2025-12-10 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 11:49
Articles in Press	2025-12-10 11:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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