Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113757
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Comprehensive modeling of the Correa cascade in precancerous lesions of gastric cancer: Leveraging animal, cellular, and organoid systems for translational insights
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Jie Zhou, Xin-Yu Hao, Chen Wang, Ning-Ning Ren and Yan-Gang Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82575015 Beijing Natural Science Foundation 7232281 Fundamental Research Funds for the Central Universities 2025-JYB-JBGS-001
Corresponding Author	Ning-Ning Ren, PhD, Department of Spleen and Stomach, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 11 North Third Ring East Road, Chaoyang District, Beijing 100029, China. renning2024@163.com
Key Words	Precancerous lesions of gastric cancer; Correa cascade; Animal model; Cellular model; Organoid; Helicobacter pylori; Tumor microenvironment; Translational research
Core Tip	Precancerous lesions of gastric cancer (GC), including atrophic gastritis, intestinal metaplasia, and dysplasia, represent the pivotal transition in the Correa cascade. Accurate modeling of these lesions is crucial for dissecting early gastric tumorigenesis and identifying chemopreventive strategies. This scoping study systematically summarizes current precancerous lesions of GC models, including chemical- and infection-induced animal systems, transformed gastric epithelial cell lines, and organoid platforms derived from stem cells. We highlight their advantages, limitations, and recent advances such as genome editing, single-cell technologies, and immune co-culture. These insights provide a roadmap for selecting appropriate experimental systems and accelerating translational research in early GC prevention and therapy.
Citation	Zhou LJ, Hao XY, Wang C, Ren NN, Wang YG. Comprehensive modeling of the Correa cascade in precancerous lesions of gastric cancer: Leveraging animal, cellular, and organoid systems for translational insights. World J Gastrointest Oncol 2026; In press

Received	2025-09-03 08:50
Peer-Review Started	2025-09-03 08:50
First Decision by Editorial Office Director	2025-09-17 09:26
Return for Revision	2025-09-18 14:58
Revised	2025-11-28 07:46
Publication Fee Transferred	2025-12-11 03:29
Second Decision by Editor	2026-01-04 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 08:43
Articles in Press	2026-01-04 08:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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