Publication Name	World Journal of Meta-Analysis
Manuscript ID	113789
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Metabolic dysfunction-associated fatty liver disease: A key player in colorectal cancer development and progression
Manuscript Source	Invited Manuscript
All Author List	Yasser Fouad, Ziyan Pan, Alaa M Mostafa and Mohammed Eslam
Funding Agency and Grant Number
Corresponding Author	Yasser Fouad, MD, Professor, Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, El-Horria Stree, Minia 19111, Egypt. yasser.abdallah@mu.edu.eg
Key Words	Metabolic associated fatty liver disease; Colorectal carcinoma; Risk factors; Colon; Liver
Core Tip	Metabolic dysfunction-associated fatty liver disease may actively contribute to the development, progression, and outcomes of colorectal cancer in addition to coexisting with it, according to mounting epidemiological and mechanistic evidence. Obesity, type 2 diabetes, dietary patterns, and systemic inflammation are among the risk factors that overlap between the two conditions, indicating a convergent pathophysiological axis. Changing one’s lifestyle, controlling metabolic risk factors, and using new therapeutic targets like anti-inflammatory and antifibrotic drugs may help slow the progression of metabolic dysfunction-associated fatty liver disease and lower the burden of colorectal cancer. This perspective emphasises the necessity of multidisciplinary strategies aimed at prevention, early detection, and therapeutic optimisation.
Citation	Fouad Y, Pan Z, Mostafa AM, Eslam M. Metabolic dysfunction-associated fatty liver disease: A key player in colorectal cancer development and progression. World J Meta-Anal 2025; In press

Received	2025-09-05 09:00
Peer-Review Started	2025-09-05 09:00
First Decision by Editorial Office Director	2025-09-29 07:30
Return for Revision	2025-10-01 04:59
Revised	2025-10-09 19:53
Publication Fee Transferred
Second Decision by Editor	2025-12-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 06:32
Articles in Press	2025-12-11 06:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2308-3840 (online)
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