Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	113855
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Huang-Fu Ma, Jia-Hua Qian, Yi-Hao Chen, Yue Wang, Yan-Mei Wang, Jia-Nan Li, Zhang-Yun Zhou, Jian-Xiong Ma and Xue-Cheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81804092 Young Elite Scientists Sponsorship Program by CACM No. CACM-2022-QNRC2-A01 China Postdoctoral Science Foundation No. 2023M743146 Zhejiang Chinese Medical University Scientific Research Project for Talent No. 2023RCZXZK47 National Postdoctoral Research Program No. GZC20232373 China-Japan Friendship Hospital Scientific Research Fund No. 2024-ZF-12
Corresponding Author	Xue-Cheng Zhang, MD, Department of Proctology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. zhangxuecheng@zryhyy.com.cn
Key Words	Perianal abscess; Prevention; Obesity; Lipid metabolism profile; Case-control study; Mendelian randomization
Core Tip	Our case-control study revealed that the risk of perianal abscesses (PAs) was significantly correlated with various obesity/metabolic markers, including higher body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio, glucose levels, uric acid levels, cholesterol levels, triglyceride levels, and low-density lipoprotein (LDL) cholesterol levels, as well as lower levels of high-density lipoprotein cholesterol. The mendelian randomization analysis further confirmed relationships between the PA risk and factors such as BMI, WHR, large and medium LDLs, and lipid ratios. These findings suggest that lipid levels, body fat distribution, and metabolic markers are crucial to the understanding of PA risk.
Citation	Ma HF, Qian JH, Chen YH, Wang Y, Wang YM, Li JN, Zhou ZY, Ma JX, Zhang XC. Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis. World J Gastrointest Surg 2025; In press

Received	2025-09-08 05:25
Peer-Review Started	2025-09-08 05:25
To Make the First Decision
Return for Revision	2025-09-28 03:43
Revised	2025-10-11 08:01
Second Decision	2025-11-19 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-19 07:27
Articles in Press	2025-11-19 07:27
Publication Fee Transferred	2025-10-14 10:07
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Typeset the Manuscript

ISSN	1948-9366 (online)
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