Publication Name	World Journal of Experimental Medicine
Manuscript ID	113869
Country	United States

Category	Biochemistry & Molecular Biology
Manuscript Type	Observational Study
Article Title	Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination
Manuscript Source	Unsolicited Manuscript
All Author List	Natalia Lidmar Von Ranke, Wei Zhang, Philipp Anokhin, Nicolas Hulscher, Kevin McKernan, Peter Mccullough and John Catanzaro
Funding Agency and Grant Number
Corresponding Author	John Catanzaro, MD, PhD, Development of R and D, Neo7Bioscience, 2500 Summer Lee Dr, Rockwall, Dallas, TX 75032, United States. john.catanzaro@neo7bioscience.com
Key Words	Coronavirus disease; Vaccine; RNA-seq; Immune dysregulation; Cancer
Core Tip	This study demonstrates that individuals experiencing new-onset adverse events or cancer after messenger RNA (mRNA) coronavirus disease 2019 vaccination exhibit widespread transcriptomic dysregulation. Bulk RNA sequencing revealed hallmarks of mitochondrial dysfunction, systemic inflammation, proteasome and ribosomal stress, and nonsense-mediated decay, with additional genomic instability and epigenetic reprogramming in cancer patients. Notably, myelocytomatosis oncogene activation and heightened immune signaling via toll-like receptors and type I interferons were observed. These findings highlight shared and distinct molecular signatures, underscoring the need for further investigation into long-term mRNA vaccine safety and host variability.
Citation	Von Ranke NL, Zhang W, Anokhin P, Hulscher N, McKernan K, Mccullough P, Catanzaro J. Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination. World J Exp Med 2025; In press

Received	2025-09-05 09:04
Peer-Review Started	2025-09-05 09:04
To Make the First Decision
Return for Revision	2025-09-23 08:34
Revised	2025-10-01 23:14
Second Decision	2025-10-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-24 06:51
Articles in Press	2025-10-24 06:51
Publication Fee Transferred	2025-10-03 14:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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