Publication Name	World Journal of Stem Cells
Manuscript ID	113871
Country	Saudi Arabia

Category	Cell & Tissue Engineering
Manuscript Type	Editorial
Article Title	Mesenchymal stem cell secretome and exosomes as potential advanced therapy medicinal products for treating a failing heart
Manuscript Source	Invited Manuscript
All Author List	Syed Mohammad Habib, Mohammad Fateh Martini, Yacoub Nail Hamdan Abu-Hamdan, Omran Mohammed Marwan Shrebaty and Khawaja Husnain Haider
Funding Agency and Grant Number
Corresponding Author	Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Alrajhi Medical School, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. khhaider@gmail.com
Key Words	Cell-free therapy; Conditioned medium; Exosomes; Heart failure; Mesenchymal stem cells; Myocardial infarction; Secretome
Core Tip	This paper reviews advancements in the treatment and management of heart failure through cell-free therapies, including mesenchymal stem cell-derived secretomes and exosomes that deliver an array of bioactive molecules and participate in the repair process. The seven primary modules, which explain the reparative and regenerative potential of secretome and exosomes, have been discussed in the context of mechanistic understanding, drawing on published data from experimental and clinical settings that act on the myocardium to achieve the therapeutic benefits of the treatment.
Citation	Habib SM, Martini MF, Abu-Hamdan YNH, Shrebaty OMM, Haider KH. Mesenchymal stem cell secretome and exosomes as potential advanced therapy medicinal products for treating a failing heart. World J Stem Cells 2026; In press

Received	2025-09-05 03:19
Peer-Review Started	2025-09-05 03:36
First Decision by Editorial Office Director	2025-10-21 06:44
Return for Revision	2025-10-21 06:44
Revised	2025-11-17 05:59
Publication Fee Transferred
Second Decision by Editor	2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-27 08:46
Articles in Press	2026-01-27 08:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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