Publication Name	World Journal of Diabetes
Manuscript ID	113992
Country	Saudi Arabia

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model
Manuscript Source	Unsolicited Manuscript
All Author List	Mohd Adnan Kausar, Kehkashan Parveen, Sadaf Anwar, Yusuf Saleem Khan, Ayman A Saleh, Mai Ali Abdelfattah Ahmed, Waseem Ahmad Siddiqui and Suhel Parvez
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Deanship at University of Ha'il Saudi Arabia RG-24 082
Corresponding Author	Mohd Adnan Kausar, PhD, Professor, Department of Biochemistry, College of Medicine, University of Ha’il, University City-Hail, Al Khitah Street, Hail 53962, Saudi Arabia. ma.kausar@uoh.edu.sa
Key Words	Diabetes; Polyherbal extract; Oxidative stress; Inflammation; Neurotrophic factors
Core Tip	Diabetic neuropathy represents the primary complication of diabetes, characterized by oxidative stress, inflammation, and impaired neurotrophic signaling. In streptozotocin-induced diabetic rats, a polyherbal extract derived from Curcuma longa, Myristica fragrans, and Citrullus colocynthis significantly enhanced metabolic parameters, improved lipid profile and promoted antioxidant defense, and neurobehavioral outcomes. It reversed behavioral impairments and histological damage by lowering hyperglycemia, raising insulin levels, and reducing neuroinflammation and oxidative stress. These findings demonstrate the neuroprotective qualities of polyherbal extract and encourage more research into plant-based remedies for diabetic neuropathy.
Citation	Kausar MA, Parveen K, Anwar S, Khan YS, Saleh AA, Ahmed MAA, Siddiqui WA, Parvez S. Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model. World J Diabetes 2025; In press

Received	2025-09-10 06:07
Peer-Review Started	2025-09-12 05:43
First Decision by Editorial Office Director	2025-09-28 09:20
Return for Revision	2025-09-28 09:20
Revised	2025-10-19 20:06
Publication Fee Transferred	2025-10-30 07:25
Second Decision by Editor	2025-12-15 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-26 06:52
Articles in Press	2025-12-26 06:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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