Publication Name	World Journal of Hepatology
Manuscript ID	114045
Country	Portugal

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction
Manuscript Source	Unsolicited Manuscript
All Author List	Ana Isabel Ferreira, Mariana Costa Azevedo, Vitor Macedo Silva, Sofia Xavier, Joana Magalhães and José Cotter
Funding Agency and Grant Number
Corresponding Author	Ana Isabel Ferreira, MD, Gastroenterology Department, Unidade Local de Saúde do Alto Ave, R. dos Cutileiros 114, Creixomil, Guimaraes 4835-044, Portugal. ai.voferreira@gmail.com
Key Words	Autoimmune hepatitis; Metabolic dysfunction-associated steatotic liver disease; Autoantibodies; Liver biopsy; Controlled attenuation parameter
Core Tip	This retrospective study included 81 consecutive adult patients with liver dysfunction and positive autoantibodies undergoing liver biopsy. Autoimmune hepatitis was not confirmed in 47% of patients. In patients with anti-nuclear antibodies positivity, male gender and higher controlled attenuation parameter values emerged as independent predictive factors associated with non-confirmed diagnosis of autoimmune hepatitis. These findings generate a valuable hypothesis that may inform future updates to clinical decision algorithms, particularly considering the rising prevalence of metabolic dysfunction-associated steatotic liver disease.
Citation	Ferreira AI, Azevedo MC, Silva VM, Xavier S, Magalhães J, Cotter J. Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction. World J Hepatol 2025; In press

Received	2025-09-11 07:53
Peer-Review Started	2025-09-11 07:54
To Make the First Decision
Return for Revision	2025-09-23 08:21
Revised	2025-10-09 09:31
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-25 11:52
Articles in Press	2025-11-25 11:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com