Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	114189
Country	Russia

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Role of TRPM4 ion channel in pediatric arrhythmic syndromes
Manuscript Source	Invited Manuscript
All Author List	Olesya V Melnik, Olga E Kulichik, Anastasiya K Zaytseva, Olga A Kofeynikova, Svetlana G Fetisova, Svetlana I Tarnovskaya, Yuliya V Fomicheva, Elena S Vasichkina, Boris S Zhorov, Olga V Kalinina and Anna A Kostareva
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation 25-15-00552
Corresponding Author	Anna A Kostareva, Director, MD, Professor, Institute of Molecular Biology and Genetics, Department of Molecular Medicine and Cellular Biology, Institution of Medical Education,, Almazov National Medical Research Centre, Akkuratova Street, 2, Saint-Petersburg 197341, Russia. anna.kostareva@ki.se
Key Words	Transient receptor potential channels; Children; Pathophysiology; Arrhythmia; Cardiac conduction
Core Tip	TRPM4 ion channel plays a crucial role in cardiovascular system and myocardial physiology. Mutations in TRPM4 are linked to cardiac conduction disorders and arrhythmic syndromes in children. Current knowledge on the role of TRPM4 variants in pediatric arrhythmic syndromes are summarized along with a discussion of molecular mechanisms of this ion channel dysfunction. Clinical illustrations underscoring the role of TRPM4 in arrhythmic syndromes manifested in childhood are presented.
Citation	Melnik OV, Kulichik OE, Zaytseva AK, Kofeynikova OA, Fetisova SG, Tarnovskaya SI, Fomicheva YV, Vasichkina ES, Zhorov BS, Kalinina OV, Kostareva AA. Role of TRPM4 ion channel in pediatric arrhythmic syndromes. World J Clin Pediatr 2026; In press

Received	2025-09-15 03:43
Peer-Review Started	2025-09-15 03:43
First Decision by Editorial Office Director	2025-10-18 02:19
Return for Revision	2025-10-18 02:19
Revised	2025-10-31 21:10
Publication Fee Transferred
Second Decision by Editor	2026-01-27 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-27 08:02
Articles in Press	2026-01-27 08:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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