Publication Name	World Journal of Diabetes
Manuscript ID	114210
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Commentary on α-1-microglobulin as a predictor of diabetic complications
Manuscript Source	Invited Manuscript
All Author List	Li Liao, An Luo, Long-Han Zhang, Yi-Ting Pan and Ya-Qing Liu
Funding Agency and Grant Number
Corresponding Author	Li Liao, PhD, Nursing School, School of Nursing, University of South China, 28 West Changsheng Road, Hengyang 421001, Hunan Province, China. 254251558@qq.com
Key Words	α1-microglobulin; Type 2 diabetes mellitus; Machine learning models; Commentary
Core Tip	This letter comments on the recent study regarding serum α1-microglobulin (α1-MG) as a predictor of multiple complications in type 2 diabetes mellitus. The letter underscores the importance of α1-MG as a potential biomarker linking renal, retinal, neural, and cardiac complications, and highlights the need for multi-center validation and cost-effectiveness evaluation before clinical adoption.
Citation	Liao L, Luo A, Zhang LH, Pan YT, Liu YQ. Commentary on α-1-microglobulin as a predictor of diabetic complications. World J Diabetes 2025; In press

Received	2025-09-15 00:29
Peer-Review Started	2025-09-15 08:12
To Make the First Decision
Return for Revision	2025-10-17 07:21
Revised	2025-10-25 16:15
Second Decision	2025-11-19 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-19 06:16
Articles in Press	2025-11-19 06:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com