Publication Name	World Journal of Gastroenterology
Manuscript ID	114229
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond anti-inflammatory strategies: Epigenetic targets as emerging therapeutic frontiers in acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Li-Ping Liang, Le Zhang, Dan-Dan Jin, Shao-Heng Zhang and Le Liu
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Medical Research Fund No. A2403044 National Nature Science Foundation of China No. 82200612 Guangdong Basic and Applied Basic Research Foundation No. 2023A1515111183
Corresponding Author	Le Liu, MD, PhD, Principal Investigator, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Hospital, Southern Medical University, No. 1333 Xinhu Road, Shenzhen 518000, Guangdong Province, China. 1402744723@smu.edu.cn
Key Words	Acute pancreatitis; Epigenetic regulation; Rutaecarpine; FBXW11; EZH2
Core Tip	Acute pancreatitis (AP) remains without effective mechanism-based therapy beyond supportive care. This editorial emphasizes epigenetic regulation as an emerging therapeutic frontier, highlighting how the traditional Chinese medicine alkaloid rutaecarpine protects against AP via enhancer of EZH2-mediated repression of FBXW11. By integrating evidence on FBXW11 as an inflammatory biomarker, the pleiotropic actions of rutaecarpine, and the clinical availability of EZH2 inhibitors, this article outlines an epigenetic, multi-target framework for future AP interventions.
Citation	Liang LP, Zhang L, Jin DD, Zhang SH, Liu L. Beyond anti-inflammatory strategies: Epigenetic targets as emerging therapeutic frontiers in acute pancreatitis. World J Gastroenterol 2025; In press

Received	2025-09-15 02:23
Peer-Review Started	2025-09-15 02:23
First Decision by Editorial Office Director	2025-10-30 09:23
Return for Revision	2025-10-30 09:23
Revised	2025-11-14 03:07
Publication Fee Transferred
Second Decision by Editor	2025-12-04 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-04 03:16
Articles in Press	2025-12-04 03:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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