Publication Name	World Journal of Gastroenterology
Manuscript ID	114268
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Liang Yang, Hui-Ke Wang, Yong Liu, Li-Zhou Dou, Yue-Ming Zhang, Hoi-Ioi Ng, Shun He, Yihe-Bali Chi and Gui-Qi Wang
Funding Agency and Grant Number	Funding Agency Grant Number CAMS Innovation Fund for Medical Sciences 2021-I2M-1-061, 2021-I2M-1-013, 2021-1-I2M-015
Corresponding Author	Gui-Qi Wang, Academic Fellow, MD, PhD, Professor, Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. wangguiq@126.com
Key Words	Type I gastric neuroendocrine tumors; Endoscopic treatment; Neutrophil-to-lymphocyte ratio; Prognosis; Somatostatin analogues
Core Tip	Endoscopic treatment is the standard therapy for type I gastric neuroendocrine tumors, but it may not address underlying disease mechanisms. In this retrospective study of 128 patients, 41 experienced progression. Multivariate Cox regression identified adjuvant somatostatin analog use as a protective factor (hazard ratio = 0.38, 95% confidence interval: 0.17-0.90, P = 0.027) and neutrophil-to-lymphocyte ratio ≥ 2 as a risk factor (hazard ratio = 2.14, 95% confidence interval: 1.08-4.26, P = 0.030). Kaplan-Meier analysis confirmed both as independent prognostic variables. These findings suggest that combining endoscopic therapy with somatostatin analogues improves outcomes. Neutrophil-to-lymphocyte ratio may serve as a simple marker to guide risk stratification.
Citation	Yang ZL, Wang HK, Liu Y, Dou LZ, Zhang YM, Ng HI, He S, Chi YB, Wang GQ. Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study. World J Gastroenterol 2026; In press

Received	2025-09-23 10:33
Peer-Review Started	2025-09-23 10:34
First Decision by Editorial Office Director	2025-10-21 09:29
Return for Revision	2025-10-21 09:29
Revised	2025-11-07 18:22
Publication Fee Transferred	2025-11-14 09:20
Second Decision by Editor	2026-01-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 08:50
Articles in Press	2026-01-04 08:50
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ISSN	1007-9327 (print) and 2219-2840 (online)
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