Publication Name	World Journal of Clinical Oncology
Manuscript ID	114275
Country	Türkiye

Category	Oncology
Manuscript Type	Editorial
Article Title	Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade
Manuscript Source	Invited Manuscript
All Author List	Gizem Calibasi-Kocal
Funding Agency and Grant Number
Corresponding Author	Gizem Calibasi-Kocal, Department of Translational Oncology, Institute of Oncology, Dokuz Eylul University, Cumhuriyet Bulvarı 144, Alsancak, Izmir 35330, Türkiye. gizem.calibasi@deu.edu.tr
Key Words	Non-small cell lung cancer; Cisplatin resistance; Cytokines; Interleukin -6; Tumor microenvironment
Core Tip	Dai et al’s research study explores the association between inflammatory cytokines and cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Elevated levels of interleukin (IL)-6 and IL-8 were identified as key risk factors contributing to cisplatin resistance in NSCLC. Notably, IL-6 inhibition via the receptor antagonist tocilizumab restored DDP sensitivity and attenuated malignant phenotypes in resistant cell lines, by reducing cell viability, migration, and invasion, while enhancing apoptosis. These findings highlight the tumor microenvironment-cytokine interplay, particularly IL-6 signaling, as a critical determinant and potential therapeutic avenue in overcoming DDP resistance in NSCLC.
Citation	Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; In press

Received	2025-09-15 00:50
Peer-Review Started	2025-09-15 00:50
First Decision by Editorial Office Director	2025-09-22 09:17
Return for Revision	2025-09-22 09:17
Revised	2025-10-06 01:08
Publication Fee Transferred
Second Decision by Editor	2025-12-19 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 12:12
Articles in Press	2025-12-19 12:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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