Publication Name	World Journal of Gastroenterology
Manuscript ID	114416
Country	China

Category	Allergy
Manuscript Type	Letter to the Editor
Article Title	Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling
Manuscript Source	Invited Manuscript
All Author List	He-Rui Wei and Fan Xiao
Funding Agency and Grant Number
Corresponding Author	Fan Xiao, PhD, Beijing Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. xiaofan@ccmu.edu.cn
Key Words	Cholelithiasis; Succinylation; Lysine acetyltransferase 2A; Adenosine monophosphate-activated protein kinase; Protein post-translational modification
Core Tip	While the role of lysine succinylation, a significant post-translational modification, remains largely unexplored in the context of cholelithiasis, this investigation demonstrates that lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses cholelithiasis through modulation of the adenosine monophosphate-activated protein kinase/sirtuin 1 signaling axis, thereby attenuating inflammatory responses. These findings offer a transformative understanding of cholelithiasis pathogenesis and establish protein succinylation as a promising therapeutic target, effectively addressing a critical research void in this field.
Citation	Wei HR, Xiao F. Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling. World J Gastroenterol 2026; In press

Received	2025-09-19 07:26
Peer-Review Started	2025-09-19 07:26
First Decision by Editorial Office Director	2025-11-14 09:14
Return for Revision	2025-11-14 09:14
Revised	2025-11-18 02:30
Publication Fee Transferred
Second Decision by Editor	2026-01-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 11:36
Articles in Press	2026-01-04 11:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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