Publication Name	World Journal of Stem Cells
Manuscript ID	114501
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Mesenchymal stromal cell-derived extracellular vesicles as a promising therapeutic candidate for attenuating cellular senescence
Manuscript Source	Invited Manuscript
All Author List	Wei Zhang, Jing-Long Luo, Li Xiao and Jian-Guang Zhang
Funding Agency and Grant Number
Corresponding Author	Jian-Guang Zhang, PhD, /, Xiamen Institute for Food and Drug Quality Control, No. 33 Dongdu Haishan Road, Huli District, Xiamen 361012, Fujian Province, China. jianguangcn@163.com
Key Words	Mesenchymal stromal cells; Extracellular vesicles; Exosomes; Cellular senescence; Aging
Core Tip	This study by Yang et al provided evidence that clinically produced mesenchymal stromal cell-derived extracellular vesicles effectively counteract cellular senescence. They reduce senescence markers and restore collagen expression in aged human dermal fibroblasts, while mitigating oxidative stress and aging-related gene expression in a D-gal-induced aging mouse model. These results highlight the potential of mesenchymal stromal cell-derived extracellular vesicles as a ready-to-use biologic strategy against aging and aging-associated tissue damage, paving the way for their further clinical development.
Citation	Zhang W, Luo JL, Xiao L, Zhang JG. Mesenchymal stromal cell-derived extracellular vesicles as a promising therapeutic candidate for attenuating cellular senescence. World J Stem Cells 2026; In press

Received	2025-09-22 01:55
Peer-Review Started	2025-09-22 01:55
First Decision by Editorial Office Director	2025-10-24 11:06
Return for Revision	2025-10-24 11:06
Revised	2025-11-06 16:03
Publication Fee Transferred
Second Decision by Editor	2026-01-04 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 10:49
Articles in Press	2026-01-04 10:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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