Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	114574
Country	Taiwan

Category	Surgery
Manuscript Type	Editorial
Article Title	Very early recurrence in pancreatic cancer: Redefining prognostic markers and surveillance strategies
Manuscript Source	Invited Manuscript
All Author List	Riya Karmakar, Pratham Gade, Hsiang Chen Wang and Arvind Mukundan
Funding Agency and Grant Number
Corresponding Author	Arvind Mukundan, Assistant Professor, PhD, Postdoctoral Fellow, Department of Mechanical Engineering, National Chung Cheng University, No. 168 University Road, Min Hsiung, Chiayi 62102, Taiwan. arvindmukund96@gmail.com
Key Words	Pancreatic ductal adenocarcinoma; Red cell distribution width; Tumor location; Very early recurrence; Tumor; Machine learning
Core Tip	Very early recurrence within 12 weeks of pancreatic cancer surgery represents surgical failure with outcome similar to palliative care. poorly separated (grade 3) tumors, pancreatic head location, and elevated red cell distribution width are emerged as key indicators. Machine learning optimized models integrated carbohydrate antigen 19-9 and S100 calcium binding protein A2 biomarkers offer precision medicine possibility, but implementation faces continuous socioeconomic obstacles requiring healthcare system transformation and collaborative international efforts.
Citation	Karmakar R, Gade P, Wang HC, Mukundan A. Very early recurrence in pancreatic cancer: Redefining prognostic markers and surveillance strategies. World J Gastrointest Surg 2025; In press

Received	2025-09-23 06:07
Peer-Review Started	2025-09-23 06:07
To Make the First Decision
Return for Revision	2025-09-30 07:54
Revised	2025-10-06 07:37
Second Decision	2025-10-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-24 06:50
Articles in Press	2025-10-24 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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