Publication Name	World Journal of Gastroenterology
Manuscript ID	114773
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Tao Zhang, Hao Zhu, Xian-Cheng Chen, Tao Gao, Ming Chen, Zhang-Hua Zhu, Bei-Yuan Zhang and Wen-Kui Yu
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Provincial Health Commission BJ24037
Corresponding Author	Wen-Kui Yu, Chief, MD, PhD, Professor, Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. yudrnj2@163.com
Key Words	Acute pancreatitis; Severity; Organ failure; Mortality; Cohort study
Core Tip	The relationship between organ failure (OF) patterns and mortality in severe acute pancreatitis (AP) remains controversial. In this retrospective cohort of 151 patients with severe AP, we found that, after adjusting for initial multi-OF, the duration of OF, and infected pancreatic necrosis, the occurrence of new-onset OF - especially new-onset multi-OF - significantly increased both in-hospital and 90-day mortality rates. This novel perspective expands the theoretical framework linking OF patterns to adverse outcomes in AP and may prove pivotal for future pancreatitis grading systems and the design of related clinical trials.
Citation	Zhang XT, Zhu H, Chen XC, Gao T, Chen M, Zhu ZH, Zhang BY, Yu WK. New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis. World J Gastroenterol 2025; In press

Received	2025-10-10 16:25
Peer-Review Started	2025-10-10 16:25
First Decision by Editorial Office Director	2025-11-04 09:52
Return for Revision	2025-11-04 09:52
Revised	2025-11-17 16:31
Publication Fee Transferred	2025-11-18 17:17
Second Decision by Editor	2025-12-29 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 09:36
Articles in Press	2025-12-29 09:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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