Publication Name	World Journal of Gastroenterology
Manuscript ID	115336
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	MFSD2A suppresses CD8+ T cell exhaustion in colorectal cancer by inhibiting ERK/p38 MAPK-PD-L1 signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Jiong Feng, Yi-Feng Zhou, Jian-Feng Yang, Yi-Shen Mao, Wen-Li Ruan and Xiao-Feng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Medical and Health Science and Technology Planning Project of Zhejiang Province 2025KY1188 The Key Research and Development Program of Zhejiang Province 2023C03054
Corresponding Author	Xiao-Feng Zhang, Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Hangzhou 310000, Zhejiang Province, China. zhangxiaofengsy@sina.com
Key Words	Colorectal cancer; Major facilitator superfamily domain containing 2A; Extracellular signal-regulated kinase; p38 mitogen-activated protein kinase; T cell exhaustion
Core Tip	Major facilitator superfamily domain containing 2A, a known tumor suppressor and lipid transporter, is identified as a novel immune regulator in colorectal cancer. Major facilitator superfamily domain containing 2A exerts dual antitumor effects by suppressing the extracellular signal-regulated kinase/p38 mitogen-activated protein kinase-programmed death-ligand 1 signaling axis, thereby alleviating CD8+ T cell exhaustion and providing a potential strategy to overcome immunotherapy resistance in colorectal cancer.
Citation	Feng SJ, Zhou YF, Yang JF, Mao YS, Ruan WL, Zhang XF. MFSD2A suppresses CD8+ T cell exhaustion in colorectal cancer by inhibiting ERK/p38 MAPK-PD-L1 signaling. World J Gastroenterol 2026; In press

Received	2025-10-17 04:22
Peer-Review Started	2025-10-17 04:22
First Decision by Editorial Office Director	2025-11-30 01:50
Return for Revision	2025-11-30 01:50
Revised	2026-01-10 11:31
Publication Fee Transferred	2026-01-12 10:59
Second Decision by Editor	2026-03-12 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 09:05
Articles in Press	2026-03-12 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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