Publication Name	World Journal of Hematology
Manuscript ID	115355
Country	China

Category	Hematology
Manuscript Type	Retrospective Study
Article Title	Nomogram-based prediction of post-splenectomy thrombocytosis in children with hereditary spherocytosis
Manuscript Source	Invited Manuscript
All Author List	Tao Zhang, Zhong-Ce Li, Zhu-Bin Pan, Shi-Qin Qi and Ran Tang
Funding Agency and Grant Number	Funding Agency Grant Number Anhui Provincial Health and Wellness Scientific Research Project AHWJ2024Aa30300
Corresponding Author	Ran Tang, MD, Department of Pediatric Surgery, Anhui Provincial Children’s Hospital, No. 39 Wangjiang East Road, Baohe District, Hefei 231000, Anhui Province, China. njmutr@163.com
Key Words	Hereditary spherocytosis; Splenectomy; Thrombocytosis; Risk factors; Nomogram
Core Tip	Postoperative thrombocytosis is a frequent complication following splenectomy in children with hereditary spherocytosis, yet its predictors remain unclear. In this large cohort of 230 patients, we identified elevated reticulocyte count, low preoperative platelet count, and higher transfusion volume as independent risk factors. Based on these parameters, we developed and validated a nomogram with excellent discriminative power, good calibration, and strong clinical utility. This practical tool enables early risk stratification and individualized perioperative management, potentially reducing thrombotic complications and improving outcomes in pediatric hereditary spherocytosis patients undergoing splenectomy.
Citation	Zhang T, Li ZC, Pan ZB, Qi SQ, Tang R. Nomogram-based prediction of post-splenectomy thrombocytosis in children with hereditary spherocytosis. World J Hematol 2025; In press

Received	2025-10-16 14:24
Peer-Review Started	2025-10-16 14:24
First Decision by Editorial Office Director	2025-10-22 08:55
Return for Revision	2025-10-22 08:55
Revised	2025-10-24 12:42
Publication Fee Transferred
Second Decision by Editor	2025-12-29 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 09:41
Articles in Press	2025-12-29 09:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-6204 (online)
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