Publication Name	World Journal of Gastroenterology
Manuscript ID	115393
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	LIM domain only protein 7 promotes metastasis in colorectal cancer by TGF-β/ZEB1 pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Xue Bai, Bo Zheng, Xue-Mei Li, Juan-Dan Wang, Xiao-Hua Huang, Shu-Mei Fu and Xia Chen
Funding Agency and Grant Number	Funding Agency Grant Number The First Affiliated Hospital of Chengdu Medical College No. CYFY-GQ47 Health Commission of Chengdu No. 2024253 Chengdu Medical College No. 24LHXHZW1-04 Project of “CMC Talents” Peak Plan of Chengdu Medical College No. 2024kjTzn06
Corresponding Author	Xia Chen, Chief Physician, MD, Professor, Department of Gastroenterology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, No. 312 Baoguang Avenue Middle Section, Xindu District, Chengdu 610500, Sichuan Province, China. 970217858@qq.com
Key Words	LIM domain only protein 7; Colorectal cancer; Metastasis; Epithelial-mesenchymal transition; Transforming growth factor-β; Zinc finger E-box binding homeobox 1
Core Tip	LIM domain only protein 7 (LMO7) is upregulated in colorectal cancer (CRC), and is correlated with clinical stage and metastasis. It promotes CRC cell proliferation, migration, invasion, epithelial-mesenchymal transition and tumor metastasis. transforming growth factor-β induces LMO7 expression by upregulating zinc finger E-box binding homeobox 1, which binds to the LMO7 promoter, forming a transforming growth factor-β/zinc finger E-box binding homeobox 1/LMO7 axis that drives CRC progression, highlighting LMO7 as a potential therapeutic target for CRC.
Citation	Bai X, Zheng B, Li XM, Wang JD, Huang XH, Fu SM, Chen X. LIM domain only protein 7 promotes metastasis in colorectal cancer by TGF-β/ZEB1 pathway. World J Gastroenterol 2025; In press

Received	2025-10-20 09:22
Peer-Review Started	2025-10-20 09:22
First Decision by Editorial Office Director	2025-11-11 09:55
Return for Revision	2025-11-11 09:55
Revised	2025-11-22 20:30
Publication Fee Transferred	2025-11-24 08:02
Second Decision by Editor	2025-12-30 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-30 07:43
Articles in Press	2025-12-30 07:43
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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