Publication Name	World Journal of Psychiatry
Manuscript ID	115490
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma
Manuscript Source	Unsolicited Manuscript
All Author List	Shi Dong, Hui-Ling Mou, Hao Zhang and Teng Ye
Funding Agency and Grant Number
Corresponding Author	Teng Ye, Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou 325000, Zhejiang Province, China. andy325902@163.com
Key Words	Malignant melanoma; Depressive symptoms; Immune function; Cellular immunity; Inflammatory factors
Core Tip	This retrospective study revealed that over half of malignant melanoma patients experienced depressive symptoms, which were closely associated with suppressed cellular immunity and elevated inflammatory markers such as interleukin-6 (IL-6) and neutrophil-to-lymphocyte ratio. CD4+ T cell count and serum albumin were found to be protective factors, while IL-6 and advanced tumor-node-metastasis stage were risk predictors. A multi-indicator model combining IL-6, CD4+, and neutrophil-to-lymphocyte ratio achieved good predictive performance (area under the curve = 0.834). These findings highlight the need for integrated psychosocial and immunological assessment in melanoma patients to improve mental health and potentially affect prognosis.
Citation	Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2025; In press

Received	2025-11-04 09:00
Peer-Review Started	2025-11-04 09:00
First Decision by Editorial Office Director	2025-11-26 07:18
Return for Revision	2025-11-26 07:18
Revised	2025-12-08 15:08
Publication Fee Transferred	2025-12-15 08:37
Second Decision by Editor	2025-12-26 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-26 08:58
Articles in Press	2025-12-26 08:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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