Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115505
Country	China

Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Yiqi Wengyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Yu Kuang, Xiao-Yan Qin, Xin-Miao Wang, Xiao-Tong Song, Xiao-Yu Zhu and Jie Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82305347 and 82505704 Postdoctoral Fellowship Program of CPSF Under GZC20233128 Basic Research Operating Expenses Special Fund of Central Public Welfare Research Institutes ZZ16-XRZ-037 China Academy of Chinese Medical Sciences Basic Scientific Research Business Fund Outstanding Young Scientific and Technological Talents Training Project ZZ17-YQ-009
Corresponding Author	Jie Li, Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Street, Xicheng District, Beijing 100053, China. qfm2020jieli@yeah.net
Key Words	Gastric cancer; Cancer-associated fibroblasts; Yiqi Wengyang Jiedu prescription; Disulfidptosis; Traditional Chinese medicine
Core Tip	This study demonstrates that Yiqi Wenyang Jiedu prescription (YWJP) promotes disulfidptosis in gastric cancer MKN45 cells. The mechanism involves YWJP reversing the senescence of cancer-associated fibroblasts (established by transforming growth factor-β1/H₂O₂), thereby reducing the secretion of HAase. The decrease in HAase leads to the downregulation of GLUT1 and key disulfidptosis-related proteins (CYFIP1, Rac1, ARP2, ARP3). This process increases intracellular disulfide bond levels and cell death, confirming that YWJP induces disulfidptosis via the HAase/GLUT1 pathway.
Citation	Kuang ZY, Qin XY, Wang XM, Song XT, Zhu XY, Li J. Yiqi Wengyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts. World J Gastrointest Oncol 2025; In press

Received	2025-10-21 02:16
Peer-Review Started	2025-10-21 02:16
First Decision by Editorial Office Director	2025-11-10 06:21
Return for Revision	2025-11-10 06:21
Revised	2025-11-18 15:32
Publication Fee Transferred	2025-11-20 08:04
Second Decision by Editor	2025-12-30 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-30 10:12
Articles in Press	2025-12-30 10:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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