Publication Name	World Journal of Experimental Medicine
Manuscript ID	115508
Country	Uruguay

Category	Pathology
Manuscript Type	Retrospective Cohort Study
Article Title	Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas
Manuscript Source	Invited Manuscript
All Author List	Natalia González Umpiérrez, Estefania Sicco, Felipe Silveira, Aurita Veronica Beovide and Ronell Bologna-Molina
Funding Agency and Grant Number
Corresponding Author	Ronell Bologna-Molina, PhD, Professor, Department of Diagnostics in Oral Pathology and Oral Medicine, Faculty of Dentistry, University of the Republic, Las Heras 1925, Montevideo 11600, Uruguay. ronellbologna@hotmail.com
Key Words	Caveolin-1; MOC-31; Connexin-43; Ki-67; Odontogenic tumors
Core Tip	This study compared the immunohistochemical expression of caveolin-1, MOC-31, connexin-43 (Cx-43), and Ki-67 in ameloblastic fibroma (AF), ameloblastic fibrodentinoma (AFD), ameloblastic fibro-odontoma (AFO), and odontoma (O). AF, AFD, and AFO showed similar epithelial and mesenchymal profiles, with lower expression in O. Significant differences in MOC-31 and Cx-43 between AF/AFO and O suggest that AFD and AFO may represent variants of AF rather than developing odontomas. These findings contribute to understanding the biological behavior and classification of mixed odontogenic tumors.
Citation	Umpiérrez NG, Sicco E, Silveira F, Beovide AV, Bologna-Molina R. Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas. World J Exp Med 2025; In press

Received	2025-10-20 02:07
Peer-Review Started	2025-10-20 02:07
First Decision by Editorial Office Director	2025-10-23 08:35
Return for Revision	2025-10-23 08:35
Revised	2025-11-03 22:47
Publication Fee Transferred
Second Decision by Editor	2025-12-30 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-30 06:43
Articles in Press	2025-12-30 06:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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