Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115722
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities
Manuscript Source	Invited Manuscript
All Author List	Wen-Yu Luan, Shu-Ping Zhang, Kai-Zhen Xu, Yu-Hui Shang, Wen-Jian Hu, Hui Sun and Yan-Dong Miao
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Province Medical and Health Science and Technology Development Plan Project 202203030713 Yantai Science and Technology Program 2024YD005 Yantai Science and Technology Program 2024YD007 Yantai Science and Technology Program 2024YD010 Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University YTFY2022KYQD06
Corresponding Author	Yan-Dong Miao, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. miaoyd_22@bzmc.edu.cn
Key Words	Colorectal cancer; Gut microbiota; Immunometabolism; Tumor microenvironment; Metabolic reprogramming
Core Tip	The treatment of colorectal cancer (CRC) faces challenges of drug resistance mediated by the tumor microenvironment (TME). This review proposes that the gut microbiota is a core regulator in reshaping CRC immune metabolism and TME. We have established an integrated framework of the “microbiota-immune metabolism-TME” axis, systematically elaborating on the mechanisms of CRC occurrence, development, and treatment resistance from the micro level to the macro level. This perspective provides new ideas for deconstructing complexities such as clinical drug resistance. Based on this, we further explore translational strategies targeting the microbiota to reverse immunosuppression, enhance the efficacy of radiotherapy, chemotherapy, and immunotherapy, offering innovative theoretical basis and intervention prospects for the precise treatment of CRC.
Citation	Luan WY, Zhang SP, Xu KZ, Shang YH, Hu WJ, Sun H, Miao YD. Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2025; In press

Received	2025-10-24 02:49
Peer-Review Started	2025-10-24 02:50
First Decision by Editorial Office Director	2025-11-18 10:59
Return for Revision	2025-11-20 06:46
Revised	2025-12-09 07:19
Publication Fee Transferred
Second Decision by Editor	2025-12-30 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-30 08:30
Articles in Press	2025-12-30 08:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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