Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	115780
Country	Italy

Category	Pediatrics
Manuscript Type	Letter to the Editor
Article Title	Role of plasma D-dimer levels as diagnostic and prognostic marker in neonatal sepsis: An insightful support
Manuscript Source	Invited Manuscript
All Author List	Alessandro Boscarelli
Funding Agency and Grant Number
Corresponding Author	Alessandro Boscarelli, MD, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, via dell'Istria, 65/1, Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it
Key Words	D-dimer; Neonatal sepsis; Diagnosis; Prognosis; Assessment tool
Core Tip	Despite advances in neonatal care, sepsis remains a serious health problem with significant morbidity and mortality. Clinical diagnosis at presentation is often challenging due to nonspecific signs and symptoms. Laboratory biomarkers, blood cultures, and other diagnostic/prognostic tools are not considered reliable for routine clinical use. Basiouny et al conducted a two-center prospective case-control study investigating the diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis. While future multicenter studies with larger patient populations are required, these findings indicate the utility of D-dimer inclusion in sepsis diagnostic models.
Citation	Boscarelli A. Role of plasma D-dimer levels as diagnostic and prognostic marker in neonatal sepsis: An insightful support. World J Clin Pediatr 2025; In press

Received	2025-10-25 09:04
Peer-Review Started	2025-10-25 09:04
First Decision by Editorial Office Director	2025-10-30 08:54
Return for Revision	2025-10-30 08:54
Revised	2025-11-06 16:58
Publication Fee Transferred
Second Decision by Editor	2025-12-04 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-04 06:04
Articles in Press	2025-12-04 06:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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