Publication Name	World Journal of Hepatology
Manuscript ID	116074
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Rui Zhang, Ling She, Yi-Rong Cao and Yuan-Wen Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation of China No. 82270620 Key Department Project of Huadong Hospital No. ZDXK2213
Corresponding Author	Yuan-Wen Chen, MD, PhD, Department of Gastroenterology, Huadong Hospital, Fudan University, No. 221 West Yan’an Road, Shanghai 200000, China. chenywhdgi@fudan.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; High-fat diet; Gut dysbiosis; Oxidative stress; Intestinal barrier dysfunction
Core Tip	This review proposes a unifying framework in which a high-fat diet, gut dysbiosis, and oxidative stress form a self-reinforcing pathogenic triad driving metabolic dysfunction-associated steatotic liver disease. We synthesize evidence showing how diet-induced microbial imbalance disrupts intestinal barrier integrity, promotes endotoxemia, and amplifies hepatic oxidative stress, mitochondrial dysfunction, inflammation, and fibrosis. By positioning oxidative stress as a central mechanistic nexus linking diet and microbiota, this review highlights antioxidant-based lifestyle, nutritional, and pharmacological strategies as promising, integrative approaches for prevention and treatment.
Citation	Zhang ZR, She L, Cao YR, Chen YW. High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis. World J Hepatol 2026; In press

Received	2025-11-02 13:19
Peer-Review Started	2025-11-02 13:19
First Decision by Editorial Office Director	2025-12-12 08:41
Return for Revision	2025-12-12 08:41
Revised	2025-12-29 13:35
Publication Fee Transferred	2026-01-08 14:26
Second Decision by Editor	2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-27 06:45
Articles in Press	2026-01-27 06:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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