Publication Name	World Journal of Clinical Oncology
Manuscript ID	116090
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond sensitivity and specificity: Redefining the era connotation of “low-risk” in pancreatic cancer screening
Manuscript Source	Invited Manuscript
All Author List	Rui-Gang Wang
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Tsinghua Changgung Hospital Youth Fund 12021C1011 the Capital Medical Science and Technology Innovation Achievement Transformation Optimization Promotion Plan YC202501QX0920
Corresponding Author	Rui-Gang Wang, MD, Department of Gastroenterology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing 102218, China. doctorwrg@163.com
Key Words	Pancreatic cancer screening; Low-risk redefinition; Dynamic risk stratification; Precision prevention; Multimodal integration
Core Tip	This commentary argues that the conventional "low-risk" label for pancreatic cancer (PC), based solely on family history and known genetic syndromes, is obsolete. We propose a paradigm shift towards a dynamic, multidimensional risk model. This framework continuously integrates polygenic risk scores (PRS), liquid biopsy biomarkers (e.g., circulating tumor DNA), lifestyle factors, and artificial intelligence to enable real-time, personalized risk stratification. This approach can reclassify a significant portion of the "low-risk" population, paving the way for precision screening and potentially transforming early detection strategies for this lethal malignancy.
Citation	Wang RG. Beyond sensitivity and specificity: Redefining the era connotation of “low-risk” in pancreatic cancer screening. World J Clin Oncol 2025; In press

Received	2025-11-02 11:22
Peer-Review Started	2025-11-02 11:22
First Decision by Editorial Office Director	2025-11-26 09:07
Return for Revision	2025-11-26 09:07
Revised	2025-11-26 14:49
Publication Fee Transferred
Second Decision by Editor	2025-12-29 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 10:01
Articles in Press	2025-12-29 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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