Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116104
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	MicroRNA-206 suppresses hypoxia-inducible factor-1α/PFKFB3-mediated glycolysis to inhibit recurrence and metastasis of hepatocellular carcinoma after incomplete radiofrequency ablation
Manuscript Source	Unsolicited Manuscript
All Author List	Dong Lu, Li-Jun Wang, Jie Chai, Jun Jiang and Yan-Lin Tang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project Supported by Anhui Health and Scientific Research Foundation AHWJ2024Aa10119 Key Research and Development Projects of Anhui Province 201904a07020091
Corresponding Author	Dong Lu, MD, PhD, Department of Interventional Radiology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. hyjh2004@126.com
Key Words	MicroRNA-206; Hypoxia-inducible factor-1α; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Glycolysis; Incomplete radiofrequency ablation; Hepatocellular carcinoma; Tumor recurrence; Angiogenesis
Core Tip	Incomplete radiofrequency ablation (iRFA) creates a hypoxic microenvironment that drives hepatocellular carcinoma recurrence. This study reveals that microRNA-206 (miR-206) directly targets hypoxia-inducible factor-1α and suppresses PFKFB3-mediated glycolysis, thereby reducing angiogenesis, migration, and metastasis after iRFA. Using patient samples, endothelial cell models, and a rabbit VX2 tumor model, we demonstrate that restoring miR-206 expression counteracts post-ablation metabolic reprogramming. These findings highlight miR-206 as a promising therapeutic target to prevent recurrence and improve long-term outcomes after local ablation therapy in hepatocellular carcinoma.
Citation	Lu D, Wang LJ, Chai J, Jiang J, Tang YL. MicroRNA-206 suppresses hypoxia-inducible factor-1α/PFKFB3-mediated glycolysis to inhibit recurrence and metastasis of hepatocellular carcinoma after incomplete radiofrequency ablation. World J Gastrointest Oncol 2026; In press

Received	2025-11-03 06:57
Peer-Review Started	2025-11-03 06:57
First Decision by Editorial Office Director	2025-11-14 09:30
Return for Revision	2025-11-15 15:31
Revised	2025-11-19 07:10
Publication Fee Transferred	2025-11-21 03:39
Second Decision by Editor	2026-01-04 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 14:36
Articles in Press	2026-01-04 14:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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