Publication Name	World Journal of Gastroenterology
Manuscript ID	116142
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Relation between cortisol and metabolic-dysfunction associated steatotic liver disease: A dog chasing its tail
Manuscript Source	Unsolicited Manuscript
All Author List	Cesare Morgante, Calogero Camma, Salvatore Petta, Valentina Guarnotta and Giorgio Arnaldi
Funding Agency and Grant Number
Corresponding Author	Giorgio Arnaldi, Full Professor, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Endocrinology, University of Palermo, Piazza delle Cliniche 2, Palermo 90127, Sicilia, Italy. giorgio.arnaldi@unipa.it
Key Words	Metabolic dysfunction associated steatotic liver disease; Cushing syndrome; Liver; Hypercortisolism; Hepatic steatosis; Metabolic syndrome; Non-alcoholic fatty liver disease
Core Tip	Hypercortisolism and metabolic dysfunction-associated steatotic liver disease share multiple comorbidities, with a higher prevalence of metabolic dysfunction-associated steatotic liver disease in Cushing’s syndrome, indicating cortisol may contribute to liver pathogenesis. As a key target and major metabolic site of cortisol, the liver is integral to the hypothalamic-pituitary-adrenal axis. This minireview summarizes their association, underlying molecular pathways, and cortisol metabolites as potential liver biomarkers.
Citation	Morgante C, Camma C, Petta S, Guarnotta V, Arnaldi G. Relation between cortisol and metabolic-dysfunction associated steatotic liver disease: A dog chasing its tail. World J Gastroenterol 2026; In press

Received	2025-11-04 04:58
Peer-Review Started	2025-11-04 04:58
First Decision by Editorial Office Director	2025-12-18 09:42
Return for Revision	2025-12-18 09:42
Revised	2025-12-21 19:01
Publication Fee Transferred
Second Decision by Editor	2026-03-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-03 09:59
Articles in Press	2026-03-03 09:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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