Publication Name	World Journal of Stem Cells
Manuscript ID	116228
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Editorial
Article Title	X inactive specific transcript drives mitochondrial metabolic rewiring and neural stem cell fate after spinal cord injury
Manuscript Source	Invited Manuscript
All Author List	Jin-Ke Sun, Zhen Shi, Xiao-Dong Tang, Bo-Kang Lv, Peng-Yu Lu, Yi-Gong Tian, Yan-Wei Fan and Peng Yan
Funding Agency and Grant Number	Funding Agency Grant Number Key Scientific Research Projects of Colleges and Universities in Henan Province 26A320038 Henan Province Medical Science and Technology Research Plan Project (Joint Construction) LHGJ20250403, LHGJ20220566, LHGJ20240365 Key Research and Development Program of Henan Province 231111311000 Medical Education Research Project in Henan Province WJLX2023079
Corresponding Author	Peng Yan, MD, Professor, Third Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. summun1980@sina.com
Key Words	Carnitine palmitoyltransferase 1A; Insulin like growth factor 2 messenger RNA binding protein 2; Long noncoding RNA; Mitochondrial metabolism; Neural stem cells; Regenerative medicine; Spinal cord injury; X inactive specific transcript
Core Tip	This study highlights the pivotal role of the long noncoding RNA X inactive specific transcript as a metabolic-epigenetic regulator in spinal cord injury. By stabilizing carnitine palmitoyltransferase 1A messenger RNA through insulin like growth factor 2 messenger RNA binding protein 2, it enhances fatty acid oxidation and mitochondrial oxidative phosphorylation, promoting neural stem cell differentiation and functional recovery. The proposed framework integrates mitochondrial metabolism, lineage regulation, and regenerative strategies, providing a conceptual bridge from molecular mechanisms to translational medicine.
Citation	Sun JK, Shi Z, Tang XD, Lv BK, Lu PY, Tian YG, Fan YW, Yan P. X inactive specific transcript drives mitochondrial metabolic rewiring and neural stem cell fate after spinal cord injury. World J Stem Cells 2026; In press

Received	2025-11-06 06:54
Peer-Review Started	2025-11-06 06:55
First Decision by Editorial Office Director	2026-01-09 07:58
Return for Revision	2026-01-09 07:58
Revised	2026-01-16 15:39
Publication Fee Transferred
Second Decision by Editor	2026-02-28 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-28 07:24
Articles in Press	2026-02-28 07:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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