Publication Name	World Journal of Gastroenterology
Manuscript ID	116337
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Li, Sha-Sha Tao, Yan Wang, Qian Sun, Meng-Ying Li, Hua Zhang and Yun-Qing Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82504388 National Natural Science Foundation of China No. 82471254 National Natural Science Foundation of China No. 82221001 Key Research and Development Program of Shaanxi Province No. 2022SF160
Corresponding Author	Yun-Qing Li, PhD, Professor, College of Life Sciences, Northwest University, No. 229 Taibai North Road, Beilin District, Xi’an 710069, Shaanxi Province, China. deptanat@fmmu.edu.cn
Key Words	Ulcerative colitis; Cyclic adenosine monophosphate-dependent protein kinase signaling; Enteric glial cells; Enteric nervous system; Enteric nervous network
Core Tip	Salidroside (Sal) exerts protective effects in dextran sulfate sodium-induced colitis by modulating enteric glial cell (EGC) activity. Sal suppresses pathological EGC activation, reducing inflammatory mediators such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and nuclear factor kappa-B, while enhancing glial cell line-derived neurotrophic factor (GDNF) production. These effects restore mucosal barrier integrity, normalize intestinal permeability, and improve epithelial tight junction structure. Mechanistically, Sal activates the cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein signaling pathway, linking EGC regulation to anti-inflammatory outcomes. This study highlights Sal as a promising therapeutic agent for ulcerative colitis, emphasizing the critical role of the enteric nervous system and EGCs in maintaining intestinal homeostasis.
Citation	Li Y, Tao SS, Wang Y, Sun Q, Li MY, Zhang H, Li YQ. Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses. World J Gastroenterol 2026; In press

Received	2025-11-17 12:00
Peer-Review Started	2025-11-17 12:00
First Decision by Editorial Office Director	2025-12-29 09:25
Return for Revision	2025-12-29 09:25
Revised	2026-01-13 13:13
Publication Fee Transferred	2026-01-15 07:25
Second Decision by Editor	2026-03-06 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 07:47
Articles in Press	2026-03-06 07:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com