Publication Name	World Journal of Psychiatry
Manuscript ID	116435
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Han-Xu Deng, Yao-Zhi Liu, Lin Yang, Jun-Jun Liu, Feng-Nan Jia, Xue-Li Zhao, Xing-Zhi Xia, Xiang-Yang Zhang and Xiang-Dong Du
Funding Agency and Grant Number	Funding Agency Grant Number Medical research key project of Jiangsu Provincial Health Commission No. K2023015 Suzhou Major Diseases Clinical Multi-Center Research Project No. DZXYJ202414 Scientific and Technological Key Program of Suzhou No. SYW2024008 Key Discipline of Psychiatry in Suzhou No. SZXK202521
Corresponding Author	Xiang-Dong Du, Chief Physician, Professor, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Suzhou 215004, Jiangsu Province, China. xiangdong-du@163.com
Key Words	Thyroid-stimulating hormone; Suicide attempts; Thyroid dysfunction; First-episode drug naïve; Major depressive disorder; Non-linear relationship
Core Tip	This study investigates the relationship between thyroid-stimulating hormone (TSH) levels and suicide attempts in first-episode drug-naïve major depressive disorder patients. The results show a positive independent correlation between TSH levels and suicide attempts, with a significant increase in the correlation when TSH exceeds 5.43 µIU/mL. This finding provides a new biomarker-based perspective for early suicide risk identification in depressed patients.
Citation	Deng HX, Liu YZ, Yang L, Liu JJ, Jia FN, Zhao XL, Xia XZ, Zhang XY, Du XD. Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder. World J Psychiatry 2026; In press

Received	2025-11-12 08:05
Peer-Review Started	2025-11-12 08:05
First Decision by Editorial Office Director	2025-12-23 09:59
Return for Revision	2025-12-23 09:59
Revised	2026-01-06 05:11
Publication Fee Transferred	2026-01-19 06:12
Second Decision by Editor	2026-02-28 02:28
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-28 02:43
Articles in Press	2026-02-28 02:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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