Publication Name	World Journal of Hepatology
Manuscript ID	116542
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Liver injury after COVID-19 vaccination: Current status and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Ken Sato
Funding Agency and Grant Number
Corresponding Author	Ken Sato, MD, PhD, Professor, Department of Healthcare Informatics, Takasaki University of Health and Welfare, 37-1 Nakaorui-machi, Takasaki 370-0033, Japan. satoken@gunma-u.ac.jp
Key Words	SARS-CoV-2; COVID-19; Vaccination; Liver injury; Autoimmunity
Core Tip	Liver injury following coronavirus disease 2019 vaccination presents with heterogeneous phenotypes, including new-onset autoimmune hepatitis, drug-induced autoimmune-like hepatitis, drug-induced liver injury, and secondary hepatic manifestations linked to comorbidities such as hemophagocytic lymphohistiocytosis. Vaccine-type differences in liver injury remain inconclusive. Prognosis varies by etiology; although many cases resolve spontaneously or respond to immunosuppressive therapy, some progress to acute liver failure necessitating transplantation or resulting in death. Vaccine rechallenge may not be contraindicated, but switching vaccine platforms is advised. The pathogenesis likely involves multifactorial mechanisms, such as genetic predispositions and immunological cross-reactivity between viral-specific antigens and host self-proteins.
Citation	Sato K. Liver injury after COVID-19 vaccination: Current status and future perspectives. World J Hepatol 2026; In press

Received	2025-11-17 03:48
Peer-Review Started	2025-11-17 07:24
First Decision by Editorial Office Director	2026-01-08 09:25
Return for Revision	2026-01-09 07:51
Revised	2026-01-18 08:38
Publication Fee Transferred
Second Decision by Editor	2026-03-12 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 08:24
Articles in Press	2026-03-12 08:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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