Publication Name	World Journal of Psychiatry
Manuscript ID	116703
Country	China

Category	Psychology
Manuscript Type	Clinical Trials Study
Article Title	Clinical efficacy of Sihai Shuyu Pill-Euthyrox for thyroid nodules and real-world research on patients’ anxiety/depression
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Deng, Yu-Xing Xiao, Ling Wang and Chong Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Sichuan Medical Association No. WT2025RXSN01 Open Project of Key Laboratory of Sichuan University No. 30320220035 Scientific Research Project of Sichuan Provincial People’s Hospital No. 2021Zx09
Corresponding Author	Chong Zhang, PhD, Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, No. 32 Section 1, West Street, Qingyang District, Chengdu 610072, Sichuan Province, China. zhangchong77@yeah.net
Key Words	Sihai Shuyu Pill; Euthyrox; Thyroid nodules; Combining treatment; Anxiety; Depression; Real-world research
Core Tip	Thyroid nodules (TNs) represent a common thyroid disorder with incompletely understood pathogenesis. Patients with TNs commonly experience emotional issues, such as anxiety and depression, which can impact their quality of life and may adversely affect their treatment outcomes. In recent years, increasing research has focused on the efficacy of integrated Chinese and Western medicine approaches for TN treatment. Sihai Shuyu Pill is a traditional Chinese herbal formula comprising seaweed, kelp, clam shells, wood fragrant, dried tangerine peel, and other herbs. This formulation functions to nourish the liver, regulate qi, resolve phlegm, and disperse nodules. It is commonly used in traditional Chinese medicine to treat thyroid enlargement and TN caused by liver qi stagnation. This study aims to investigate the effectiveness of Sihai Shuyu Pill-combined Euthyrox for TNs and its effects on mental health.
Citation	Deng J, Xiao YX, Wang L, Zhang C. Clinical efficacy of Sihai Shuyu Pill-Euthyrox for thyroid nodules and real-world research on patients’ anxiety/depression. World J Psychiatry 2026; In press

Received	2025-12-26 10:06
Peer-Review Started	2025-12-26 10:06
First Decision by Editorial Office Director	2026-01-12 08:20
Return for Revision	2026-01-12 08:20
Revised	2026-02-12 09:56
Publication Fee Transferred
Second Decision by Editor	2026-04-03 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 03:34
Articles in Press	2026-04-03 03:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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