Publication Name	World Journal of Hepatology
Manuscript ID	116710
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Acute liver failure linked to OxyShred pre-workout supplement: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Sarah Householder, Noah Brazer and Ysabel C Ilagan-Ying
Funding Agency and Grant Number
Corresponding Author	Sarah Householder, Department of Internal Medicine, Yale-New Haven Hospital, 20 York Steet, New Haven, CT 06511, United States. sarah.householder@yale.edu
Key Words	Dietary supplements; Drug-induced liver injury; Herbal supplements; Garcinia cambogia; Weight loss agents; Liver transplantation; Acute liver failure; Case report
Core Tip	Pre-workout supplement (PWS) use has grown rapidly with the expanding fitness market, yet many products contain poorly regulated herbal ingredients linked to liver injury. Multi-ingredient supplements cause most herb-related hepatotoxicity, and consumers often assume they are regulated despite minimal oversight. OxyShred thermogenic fat burner (OxyShred), a popular PWS, includes several agents associated with liver damage. A healthy 31-year-old woman developed acute liver failure requiring transplantation after eight weeks of consistent OxyShred use. This case highlights the risks of unregulated supplements, the need for physician inquiry about PWS use, and the importance of stronger federal requirements for safety evidence and ingredient transparency.
Citation	Householder S, Brazer N, Ilagan-Ying YC. Acute liver failure linked to OxyShred pre-workout supplement: A case report and review of literature. World J Hepatol 2026; In press

Received	2025-11-18 07:48
Peer-Review Started	2025-11-18 07:48
First Decision by Editorial Office Director	2025-11-30 01:29
Return for Revision	2025-11-30 01:29
Revised	2025-12-14 21:55
Publication Fee Transferred
Second Decision by Editor	2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-27 05:28
Articles in Press	2026-01-27 05:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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