Publication Name	World Journal of Hepatology
Manuscript ID	116712
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Saikosaponin-d alleviates hepatic stellate cell activation and liver fibrosis by inhibiting the TGF-β1/Smads signaling pathway and blocking the EMT process
Manuscript Source	Invited Manuscript
All Author List	Jing Li, Meng-Xing Cao, Jun-Min Wang, Yi-Yuan Zheng, Ren-Ye Que and Liu-Bing Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82304932 Traditional Chinese Medicine Research Project of Shanghai Municipal Health Commission 2022QN051
Corresponding Author	Ren-Ye Que, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Shanghai 200082, China. 824492@qq.com
Key Words	Saikosaponin-d; Transforming growth factor-β1/Smads; Epithelial-mesenchymal transition; Liver fibrosis; Mechanism
Core Tip	Saikosaponin-d (SSd) is a promising therapeutic agent and potential antifibrotic drug. This study, through in vivo and in vitro models, demonstrates that SSd alleviates hepatic stellate cell activation and liver fibrosis progression by inhibiting the transforming growth factor-β1/Smads signaling pathway and effectively blocking the epithelial-mesenchymal transition process. The study also addresses the reversibility and safety issues of SSd, proposing solutions. These findings enrich the understanding of SSd’s antifibrotic molecular mechanisms and provide a theoretical basis for drug optimization and improvement.
Citation	Li J, Cao MX, Wang JM, Zheng YY, Que RY, Lin LB. Saikosaponin-d alleviates hepatic stellate cell activation and liver fibrosis by inhibiting the TGF-β1/Smads signaling pathway and blocking the EMT process. World J Hepatol 2016; In press

Received	2025-11-19 07:25
Peer-Review Started	2025-11-19 09:27
First Decision by Editorial Office Director	2025-12-04 08:54
Return for Revision	2025-12-04 08:54
Revised	2025-12-17 12:50
Publication Fee Transferred
Second Decision by Editor	2026-03-12 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 07:24
Articles in Press	2026-03-12 07:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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