Publication Name	World Journal of Gastroenterology
Manuscript ID	116827
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Magnetic resonance imaging predicts perianal fistula in Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Peng Xu, Lu Li, Gui-Dong Sun, Yan-Yan Wu, Er-Wei Cai, Ke Wen, Wan-Jin Shao and Yu-Gen Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82405396
Corresponding Author	Yu-Gen Chen, MD, PhD, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210029, Jiangsu Province, China. yugen.chen@njucm.edu.cn
Key Words	Magnetic resonance imaging; Perianal fistula in Crohn’s disease; Cryptoglandular anal fistula; Transmural inflammation; Active proctitis
Core Tip	This study confirms the high value of magnetic resonance imaging (MRI) in predicting perianal fistula in Crohn’s disease (PFCD) and distinguishing it from cryptoglandular anal fistula. Transmural inflammation or active proctitis on MRI are key PFCD features, with the predictive model showing 82.6% of sensitivity and 80.8% of specificity in the discovery cohort, and even better performance in external validation. Therefore, MRI serves as a reliable non-invasive tool for early PFCD diagnosis, guiding rational treatment and helping to avoid unnecessary harm to patients.
Citation	Xu ZP, Li L, Sun GD, Wu YY, Cai EW, Wen K, Shao WJ, Chen YG. Magnetic resonance imaging predicts perianal fistula in Crohn’s disease. World J Gastroenterol 2026; In press

Received	2026-02-10 09:48
Peer-Review Started	2026-02-10 09:48
First Decision by Editorial Office Director	2026-03-03 07:31
Return for Revision	2026-03-03 07:31
Revised	2026-03-23 14:19
Publication Fee Transferred
Second Decision by Editor	2026-05-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-12 09:55
Articles in Press	2026-05-12 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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