Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116937
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Wang, Ting-Yu Zhang, Yan-Feng Shen, Na Shen and Zhi-Wei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Cooperative Project of the Affiliated Hospital of Hebei University of Engineering KFKT2024-05 Precision Medicine Joint Cultivation Fund Project of Hebei Natural Science Foundation H2021402007 Science Research Project of Hebei Education Department QN2020234 Handan Key Laboratory Project of Precision Diagnosis and Treatment of Digestive Tract Cancer 23313014021 Scientific Research Project of the Administration of Traditional Chinese Medicine of Hebei Province 2022149
Corresponding Author	Zhi-Wei Zhang, PhD, Vice Director, Department of Oncology, Affiliated Hospital of Hebei University of Engineering, No. 81 Congtai Road, Congtai District, Handan 056002, Hebei Province, China. zhangzw128@126.com
Key Words	Gastric cancer; TCHP; Proliferation; Apoptosis; AKT; BCL2
Core Tip	The function and molecular mechanism of TCHP is poorly understood in gastric cancer (GC). This study investigated the role of the centrosomal protein TCHP in GC progression. TCHP was highly expressed in GC cells, and it significantly inhibited cell proliferation, arrested the cell cycle at G1 phase, and promoted apoptosis. Proteomic analysis revealed that TCHP influenced apoptosis via AKT/BCL2 pathway. In vivo experiments further confirmed that TCHP knockdown suppressed tumor growth. These results demonstrate that TCHP promotes GC proliferation and inhibits apoptosis by activating the AKT/BCL2 pathway, suggesting its potential as a therapeutic target in GC.
Citation	Wang Y, Zhang TY, Shen YF, Shen N, Zhang ZW. TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway. World J Gastrointest Oncol 2026; In press

Received	2025-11-26 03:36
Peer-Review Started	2025-11-26 03:43
First Decision by Editorial Office Director	2025-12-12 08:00
Return for Revision	2025-12-12 08:00
Revised	2026-01-11 10:31
Publication Fee Transferred	2026-01-16 03:58
Second Decision by Editor	2026-03-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-03 09:14
Articles in Press	2026-03-03 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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