Publication Name	World Journal of Psychiatry
Manuscript ID	117183
Country	China

Category	Psychiatry
Manuscript Type	Prospective Study
Article Title	Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates
Manuscript Source	Unsolicited Manuscript
All Author List	Juan Ma and Yan-Yan Jiang
Funding Agency and Grant Number
Corresponding Author	Yan-Yan Jiang, MD, Department of Obstetrics, Maternal and Child Health Care Hospital of Shandong Provincial, Affiliated to Qingdao University, No. 238 Jingshi East Road, Jinan 250014, Shandong Province, China. yyj18769782656@yeah.net
Key Words	Preeclampsia; Perinatal depression; Anxiety; Placental biomarkers; Soluble fms-like tyrosine kinase-1/placental growth factor ratio; Cortisol; Hypothalamic-pituitary-adrenal axis
Core Tip	This study highlights the strong association between preeclampsia and elevated perinatal anxiety and depressive symptoms, emphasizing the need for integrated obstetric-psychiatric care. By simultaneously assessing placental dysfunction biomarkers and neuroendocrine stress indicators, the study provides novel evidence for biological pathways linking preeclampsia with mental health vulnerability. Elevated soluble fms-like tyrosine kinase-1/placental growth factor ratios and increased morning cortisol were independently correlated with symptom severity, suggesting potential value in early risk stratification. These findings underscore the importance of routine psychological screening during pregnancy complicated by preeclampsia and support the development of targeted interventions to improve maternal mental health outcomes.
Citation	Ma J, Jiang YY. Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates. World J Psychiatry 2026; In press

Received	2026-01-16 09:48
Peer-Review Started	2026-01-16 09:48
First Decision by Editorial Office Director	2026-01-27 06:33
Return for Revision	2026-01-27 06:33
Revised	2026-02-03 16:57
Publication Fee Transferred	2026-02-12 13:25
Second Decision by Editor	2026-03-13 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 05:22
Articles in Press	2026-03-13 05:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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