Publication Name	World Journal of Gastroenterology
Manuscript ID	117194
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Zhang, Chen Zhu, Su-Hong Xia, Ming-Yu Zhang, Yi-Ran Liu, Jia-Lun Guan, Yu-Jie Huang, Kai Zhao, Jia-Zhi Liao and Wen-Juan Fan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82100568 Key Research and Development Program of Hubei Province of China 2023BCB003
Corresponding Author	Wen-Juan Fan, Associate Chief Physician, PhD, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. juanwenfan1989@tjh.tjmu.edu.cn
Key Words	Irritable bowel syndrome; Anti-HuD autoantibody; Enteric neuron; Apoptosis; Intervention
Core Tip	Current evidence indicates that immune dysregulation contributes to the pathogenesis of irritable bowel syndrome (IBS). However, the direct effects of autoantibodies on the enteric nervous system are unclear. This study established an antibody-mediated IBS model and demonstrated that anti-HuD autoantibodies directly induced enteric neuronal apoptosis by disrupting HuD-mediated RNA regulation. HuD autoantibodies reduced the stability of downstream mRNA and suppressed phosphatidylinositol 3-kinase-protein kinase B signaling, leading to neuronal loss and IBS-like gastrointestinal dysfunction. Pharmacological activation of protein kinase C restored HuD expression and alleviated neuronal apoptosis, highlighting a potential targeted therapeutic strategy for IBS associated with autoimmune-mediated enteric neuropathy.
Citation	Zhang Y, Zhu C, Xia SH, Zhang MY, Liu YR, Guan JL, Huang YJ, Zhao K, Liao JZ, Fan WJ. Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention. World J Gastroenterol 2026; In press

Received	2025-12-03 02:50
Peer-Review Started	2025-12-03 09:27
First Decision by Editorial Office Director	2025-12-30 07:50
Return for Revision	2025-12-30 07:50
Revised	2026-01-30 20:08
Publication Fee Transferred	2026-02-02 03:35
Second Decision by Editor	2026-03-16 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 09:38
Articles in Press	2026-03-17 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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