Publication Name	World Journal of Stem Cells
Manuscript ID	117241
Country	Pakistan

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells
Manuscript Source	Invited Manuscript
All Author List	Bushra Bashir, Mahmood S Choudhery and Ijaz Hussain
Funding Agency and Grant Number
Corresponding Author	Mahmood S Choudhery, Department of Human Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia, Lahore 54000, Punjab, Pakistan. ms20031@yahoo.com
Key Words	Mesenchymal stem cells; Skin rejuvenation; Hypoxic preconditioning; Regenerative potential; Anti-aging therapy
Core Tip	Mesenchymal stem cells (MSCs) exhibit age-related decline in their regenerative potential. Hypoxic preconditioning has been found to be an effective strategy to augment their regenerative potential. Aged adipose tissue derived MSCs subjected to hypoxic preconditioning (3% O2) for 48 hours exhibited enhanced proliferative potential, clonogenicity, differentiation capability, concurrent with reduced senescence. These findings suggest that hypoxic-preconditioning is a promising therapeutic option to enhance the regenerative potential of aged adipose tissue derived MSCs for autologous use.
Citation	Bashir B, Choudhery MS, Hussain I. Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells. World J Stem Cells 2026; In press

Received	2025-12-02 01:17
Peer-Review Started	2025-12-02 01:17
First Decision by Editorial Office Director	2025-12-26 10:25
Return for Revision	2025-12-26 10:25
Revised	2026-01-06 08:08
Publication Fee Transferred
Second Decision by Editor	2026-03-05 02:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 07:07
Articles in Press	2026-03-12 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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