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Articles in Press
3/20/2026 4:42:43 AM | Browse: 8 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Qi Yue, Yi-Wu Yuan, He-Song Xu, Xue-Qin Li, Jin-Heng Gan, Yong-Hui Zou, Luo-Jun Fan and Lin Xin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82573536 |
| National Natural Science Foundation of China |
No. 82360591 |
| Science and Technology Plan of Jiangxi Provincial Health and Wellness Committee |
No. 202510043 |
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| Corresponding Author |
Lin Xin, Academic Fellow, Chief Physician, FRCS (Gen Surg), Professor, Researcher, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. xindoctor0504@126.com |
| Key Words |
Tropomyosin 3; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Mitogen-activated protein kinase signaling pathway; Gastric cancer; Molecular mechanism |
| Core Tip |
In this study, we investigated the role of tropomyosin 3 (TPM3) in gastric cancer (GC). We found that TPM3 is highly expressed in GC tissues and is associated with poor prognosis. Mechanistically, TPM3 promotes GC cell proliferation, invasion, and metastasis through interaction with tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma and subsequent activation of the mitogen-activated protein kinase signaling pathway. Both in vitro and in vivo experiments demonstrated that the TPM3/tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma axis plays a critical role in GC progression. |
| Citation |
Yue ZQ, Yuan YW, Xu HS, Li XQ, Gan JH, Zou YH, Fan LJ, Xin L. Tropomyosin 3 regulates tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma to promote malignant progression in gastric cancer. World J Gastroenterol 2026; In press |
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Received |
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2025-12-05 01:18 |
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Peer-Review Started |
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2025-12-05 01:18 |
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First Decision by Editorial Office Director |
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2026-01-28 09:20 |
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Return for Revision |
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2026-01-28 09:20 |
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Revised |
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2026-02-15 08:35 |
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Publication Fee Transferred |
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2026-02-25 10:08 |
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Second Decision by Editor |
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2026-03-20 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-20 04:42 |
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Articles in Press |
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2026-03-20 04:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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