Publication Name	World Journal of Hepatology
Manuscript ID	117406
Country	Egypt

Category	Biology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Immune-transcriptomic profiles in peripheral blood mononuclear cells highlight early dysregulation in adolescent non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Noura A A Ebrahim, Aya Arafat and Soliman M A Soliman
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Adolescent non-alcoholic fatty liver disease; Peripheral blood mononuclear cells; Immune dysregulation; Gut-liver axis; Transcriptomic profiling
Core Tip	This letter underscores the early immune disturbances in adolescents with non-alcoholic fatty liver disease (NAFLD) revealed through transcriptomic and cytokine analysis of peripheral blood mononuclear cells (PBMCs). By exposing PBMCs to autologous fecal extracts, the study recreates gut-liver interactions in vitro, highlighting how host-specific microbiota shape systemic immune responses. These results suggest that PBMC-derived immune signatures could serve as minimally invasive biomarkers and inform the development of personalized diagnostic and therapeutic strategies in pediatric NAFLD.
Citation	Ebrahim NAA, Arafat A, Soliman SMA. Letter to the Editor: Immune-transcriptomic profiles in peripheral blood mononuclear cells highlight early dysregulation in adolescent non-alcoholic fatty liver disease. World J Hepatol 2026; In press

Received	2025-12-08 00:55
Peer-Review Started	2025-12-08 00:55
First Decision by Editorial Office Director	2025-12-31 08:26
Return for Revision	2025-12-31 08:26
Revised	2026-02-05 22:01
Publication Fee Transferred
Second Decision by Editor	2026-04-24 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 06:10
Articles in Press	2026-04-24 06:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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