Publication Name	World Journal of Hepatology
Manuscript ID	117456
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Tian Yu, Mei-Han Li, Shan Tang, Chen Liang, Da-Cheng Sheng, Hui Jiang, Jian-Xia Dong, Wei Hou and Su-Jun Zheng
Funding Agency and Grant Number	Funding Agency Grant Number the National Key Research and Development Program of Ministry of Science and Technology 2022YFC2304400 Beijing Hospitals Authority’s Ascent Plan DFL20241701 High-Level Public Health Technical Talents of the Beijing Municipal Health Commission Academic Leader-02-14
Corresponding Author	Su-Jun Zheng, MD, PhD, Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitoutiao, Youwai Street, Beijing 100069, China. zhengsujun@ccmu.edu.cn
Key Words	Hyperbilirubinemia; Gilbert’s syndrome; Hemolysis; Diagnosis; Nomogram
Core Tip	Clinical characteristic overlap and the need for complex specialized testing make it challenging to distinguish uridine diphosphate glucuronosyltransferase 1A1 mutations from hemolytic diseases in patients with chronic unconjugated hyperbilirubinemia. In a genetically confirmed cohort, we applied least absolute shrinkage and selection operator and logistic regression to identify four variables for differential diagnosis: Abnormal peripheral blood smear, hematocrit, red cell distribution width standard deviation, and reticulocyte percentage. These variables were used to establish a nomogram model, which achieved an area under the receiver operating characteristic of 0.986 and an area under precision-recall curve of 0.938. This model provides a simple, interpretable, and cost-effective tool for early screening and triage, potentially reducing the need for complex testing.
Citation	Yu HT, Li MH, Tang S, Liang C, Sheng DC, Jiang H, Dong JX, Hou W, Zheng SJ. Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases. World J Hepatol 2026; In press

Received	2025-12-08 06:56
Peer-Review Started	2025-12-08 06:56
First Decision by Editorial Office Director	2026-01-06 09:03
Return for Revision	2026-01-06 09:03
Revised	2026-01-20 04:43
Publication Fee Transferred	2026-01-22 14:29
Second Decision by Editor	2026-03-03 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-03 09:07
Articles in Press	2026-03-03 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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