Publication Name	World Journal of Clinical Oncology
Manuscript ID	117460
Country	Greece

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Tsampika-Vasileia Kalamara, Dimitrios A Andreikos, Konstantinos Dodos, Elisavet Georgiou, George Fotakopoulos, Nikolaos Foroglou, Dorothea Kapoukranidou and Vasiliki E Georgakopoulou
Funding Agency and Grant Number
Corresponding Author	Vasiliki E Georgakopoulou, MD, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 17 Agiou Toma Street, Athens 11527, Greece. vaso_georgakopoulou@hotmail.com
Key Words	Chemotherapy-induced peripheral neuropathy; MicroRNA; Biomarker; Neurotoxicity; Liquid biopsy
Core Tip	This systematic review synthesizes, for the first time, the human evidence on miRNAs as minimally invasive biomarkers of chemotherapy-induced peripheral neuropathy. Across five observational studies, 30 circulating miRNAs were profiled, with a small subset (notably miR-22-3p, hsa-miR-378f and miR-3184-5p) showing differential expression in patients with CIPN. However, inconsistent signals across cancer types and regimens, together with limited sample sizes and heterogeneous methodologies, currently preclude clinical application. The review maps the most promising candidate miRNAs and delineates key design and reporting priorities needed to move miRNA-based CIPN diagnostics and prognostics towards clinical utility.
Citation	Kalamara TV, Andreikos DA, Dodos K, Georgiou E, Fotakopoulos G, Foroglou N, Kapoukranidou D, Georgakopoulou VE. MicroRNAs as diagnostic and prognostic biomarkers in chemotherapy-induced peripheral neuropathy: A systematic review. World J Clin Oncol 2026; In press

Received	2025-12-08 06:19
Peer-Review Started	2025-12-08 10:03
First Decision by Editorial Office Director	2025-12-24 09:42
Return for Revision	2025-12-24 09:42
Revised	2025-12-26 06:04
Publication Fee Transferred
Second Decision by Editor	2026-03-20 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-20 10:11
Articles in Press	2026-03-20 10:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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