Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117518
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Impact of donor-specific antibodies on immune rejection rates in liver transplantation: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Lu-Yi Zhang, Yu-Hang Ling, Hong-Quan Zhang, Cheng-Wu Tang and Qin-Liang Mo
Funding Agency and Grant Number	Funding Agency Grant Number Postgraduate Research and Innovation Project of Huzhou University 2025KYCX104
Corresponding Author	Cheng-Wu Tang, PhD, Department of General Surgery, Huzhou Key Laboratory of Translational Medicine, Huzhou First People’s Hospital, The First Affiliated Hospital of Huzhou University, No. 158 Guangchanghou Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. dr_tcw@163.com
Key Words	Donor-specific antibodies; Liver transplantation; Antibody-mediated rejection; Mean fluorescence intensity; Meta-analysis; Graft survival; Systematic review
Core Tip	This meta-analysis evaluates the impact of donor-specific antibodies (DSAs) on immune rejection following liver transplantation. While the presence of DSAs alone may not consistently predict rejection, quantitative measures - specifically high mean fluorescence intensity levels - are significantly correlated with increased rejection risk. These findings suggest that standardized, quantitative DSA monitoring, rather than simple qualitative detection, is essential for guiding personalized immunosuppressive protocols and optimizing long-term graft survival.
Citation	Zhang LY, Ling YH, Zhang HQ, Tang CW, Mo QL. Impact of donor-specific antibodies on immune rejection rates in liver transplantation: A systematic review and meta-analysis. World J Gastrointest Surg 2026; In press

Received	2026-01-16 09:44
Peer-Review Started	2026-01-16 09:44
First Decision by Editorial Office Director	2026-01-28 07:47
Return for Revision	2026-01-28 07:47
Revised	2026-02-12 05:07
Publication Fee Transferred	2026-02-24 03:32
Second Decision by Editor	2026-03-19 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-19 09:02
Articles in Press	2026-03-19 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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