Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117582
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of baseline C-reactive protein/albumin ratio for long-term outcomes in advanced gastric cancer under immunochemotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Shuai Mei, Mei-Ling Ye, Qiu-Lin Hao, Geng-Chen Li, Zhi-Yuan Yao and Hai-Yan Wang
Funding Agency and Grant Number
Corresponding Author	Hai-Yan Wang, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. xzhaiyan68@163.com
Key Words	Gastric cancer; C-reactive protein/albumin ratio; Programmed death-1 inhibitor; Predictive model; Efficacy; Safety
Core Tip	The baseline C-reactive protein/albumin ratio (CAR) is a significant independent prognostic factor for advanced gastric cancer patients receiving combination immunotherapy and chemotherapy, with lower CAR levels associated with improved progression-free survival, overall survival, and higher objective response and disease control rates. By incorporating both inflammatory and nutritional status, the CAR index provides a more comprehensive evaluation of the immune microenvironment compared to traditional single inflammatory biomarkers. The CAR-integrated nomogram shows strong predictive accuracy, guiding personalized immunotherapy strategies. However, prospective, multi-center studies are needed to validate and refine its clinical applicability.
Citation	Mei S, Ye ML, Hao QL, Li GC, Yao ZY, Wang HY. Prognostic significance of baseline C-reactive protein/albumin ratio for long-term outcomes in advanced gastric cancer under immunochemotherapy. World J Gastrointest Oncol 2026; In press

Received	2025-12-11 02:06
Peer-Review Started	2025-12-11 02:06
First Decision by Editorial Office Director	2025-12-26 09:52
Return for Revision	2025-12-26 09:52
Revised	2026-01-05 13:24
Publication Fee Transferred	2026-01-08 08:13
Second Decision by Editor	2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-27 07:36
Articles in Press	2026-01-27 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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